Has anyone noticed the Color Picker Tool doesn't function outside the KeyShot window? I've noticed this on every update since 9 was released.
The Color Picker Tool will not work outside of KeyShot on MacOS Catalina if it does not have permission to record the screen. MacOS should give you a warning the first time you use the tool, but if you did not enable it then, you can enable it in System Preferences > Security & Privacy > Privacy > Screen Recording. Click on the lock to make changes and enable KeyShot.